Ending COVID
Saturday, November 21, 2020
Outline H1N1 vs. SARS-COV-2
Thursday, November 19, 2020
Tobacco Leads to the Development of Chronic Obstructive Pulmonary Disease & Contracting Viral Respiratory Infections
Ending COVID
Smoking, Tobacco, & Second-Hand Smoke Contribute to the Development of Contracting Chronic Obstructive Pulmonary Disease, Which Increases the Susceptibility to Respiratory Based Viral Infections
Chronic Obstructive Pulmonary Disease (COPD)
When observing the major causes of death for the human population in the United States, chronic lower respiratory diseases are the 4th leading cause of death for Americans. Chronic lower respiratory diseases include: asthma, COPD, bronchitis, emphysema, lung cancer, etc. Medical ailments from these diseases can include: difficulty breathing, chest tightness, a collapse of part or all of the lung (pneumothorax or atelectasis), swelling and inflammation in the main passages (bronchial tubes) that carry air to the lungs (bronchitis), and an eventual painful suffocating death.
In order to live a healthy life, it is important to avoid things that can contribute to the decline of the immune system. When it comes to respiratory viruses, the primary organs that need to be kept in good working order are the lungs. As of 2020 the major contributor to the destruction of lung health is tobacco.
The damage that tobacco and smoking cause to lung health is significant and has resulted in it being classified as the first carcinogen and 4th leading cause of death in the United States. Usage of cigarettes or being around second hand smoke is the leading cause of COPD. Exposure to tobacco and cigarette smoke is the main cause of chronic obstructive pulmonary disease.
COPD is a condition where there is a build-up of mucus in the lungs (the mucus serves to protect epithelia cells in the linings of the respiratory system becomes inflamed). Results in a loud, congested, painful cough, along with excruciating breathing difficulties. The carcinogenic toxins found in cigarette smoke, will weaken the lungs defense against all infections, narrow the air passages, and cause swelling in air tubes and destroy air sacs—all contributing factors for chronic obstructive pulmonary disease (COPD). Injured lungs will make it difficult to inhale and exhale oxygen into and out of the body which will make it difficult to breathe.
The leading cause of COPD is smoking. Cigarette smoke can directly lead to the development of COPD symptoms and also indirectly through second hand smoking effects. Exposure to another person smoking, or being in the environment where someone has previously smoked can directly impact lung health.
The vast majority of deaths associated with tobacco are from lung diseases like cancer, chronic respiratory diseases (COPD) and tuberculosis. Lung cancer deaths are primarily caused by tobacco, with over 2/3 of lung cancer deaths worldwide. Second-hand smoke exposure anywhere will also increase the chances of acquiring lung cancer.
The single largest health preventable cause of death and disease for Americans in the United States is tobacco usage. Around 480,000 Americans die each year due to cigarette smoking. In 2018, an estimated 13.7% (34.2 million) of U.S. adults were cigarette smokers. Of these, (34.2 million) 74.6% Americans smoked every day.
In addition, tobacco/smoking-related medical illness in the US costs more than $300 billion annually, including at least $170 billion in direct medical care for adults who smoke and $156 billion in lost productivity in the American workforce due to cigarette smokers.
Respiratory system diseases/COPD
Smoking/Carcinogen/Lungs/Squamous Alveolar Cells
Asthma/Bronchitis/Lung Cancer/Death
Lung damage/weak immune system/viral infection
Regarding Second hand smoke
Long term ramifications/smoke/carcinogen in air
Home/Auto smoke free
Smoke on clothes/walls/carpets
Smoke-free apartments/restaurants/workplaces/environments
Avoid public places that allow smoking
Wednesday, November 18, 2020
Phase I/II Clinical Trial Results from COVID-19 RNA based SARS-CoV-2 Vaccine BNT162b1 in Adults
Removing Social Distancing Policies Pertaining to Social Gatherings in the United States
Ending COVID
Public Health Measures Regarding COVID Social Interactions in the US
Social Gatherings For the Holidays
The following is pertaining to the COVID situation regarding whether the American public can engage in social gatherings in private and public environments during the upcoming holiday season. At the current time it is within reason to resume all normal activities regarding social gatherings without the concern of adverse long term health ramifications concerning COVID.
The vast majority of the public has been exposed to the virus in the United States and it is no longer considered a threat. Areas of concern only pertain to the segment of the population which is immuno-compromised, such as those with pre-existing/on-going health conditions, disabilities, and the elderly.
Starting with transportation, regarding if it is appropriate to travel in automobiles, airplanes, etc. at the current time throughout the United States. Current incoming data implies that large segments of the population is utilizing public and private transportation in order to move around the country without incurring adverse health effects.
Pertaining to air travel, there are several airlines which are currently operating in the US at full capacity (booked out flights). Concerns regarding the spread of the COVID virus due to mass transport of individuals from one area to another are not relevant at this time.
Case study statistics from the states of California and Texas can be used to show that there are already millions of COVID positive individuals in the region. COVID (+) positive test results from states such as California where over a million individuals have tested positive (+) in a overall population of 39.78 million. As well as the state of Texas, which also has over a million positive COVID (+) individuals moving around the region freely (no quarantine), in a population of over 29.90 million. Both imply that the vast majority of the population has already been exposed to or infected with the COVID virus and are either mild cases or asymptomatic.
Since these are two of the most heavily populated states in the country, and both have upwards of millions of individuals who have been exposed to or infected with COVID; it is clear that the virus has surpassed any measures of containment. Enforcing public health mandates to a population at this time, will no longer have the impact intended of containing the spread of the virus (2019).
Educating the public to practice general hygiene practices in order to prevent illness and the spread of disease is a practical measure to reduce the rates of viral infections. Similar to concerns regarding preventing the spread of influenza/H1N1/SARS/flu/cold/respiratory diseases/viral/bacterial/etc.
Age specific guidelines regarding who can travel without severe health ramifications is directly corelated to the strength of the immune system. Age demographics pertaining to the level of how strong the immune system of the individual are the following. (1-5), (6-10), (11-20), (20-30) (31-40), (41-45), (46-50), (51-55),(56-60), (61-65), (66-70), (71-75), (76-80), (81-85), (86-100). Those past the age of 60 are at a higher chance of being infected with general respiratory viruses along with any individuals who have pre-existing health conditions. However the health benefits of socializing for the same age bracket far outweigh the possible negative ramifications of not.
Regarding social gatherings, transportation is clear, housing/hotel accommodations are clear. Typical gatherings involve a wide variety of people of different age demographics/ professions
Can you travel --> Yes
Safe for children --> Yes
Safe for young adults --> Yes
Safe for middle age adults --> Yes
Safe for upper middle age adults --> Yes
Safe for older adults --> likely
Safe for the elderly --> most likely (most cautious for respiratory viral exposure)
Other Concerns
Food Preparation/Smoke/Nutrition/Exertion
Accommodations/housing/sleeping/rest conditions
Proper Outer Coverings/Stay Warm/Avoid temperature fluctuations
Health benefits/social gatherings/life events/etc.
Influenza Related Deaths in the United States is the Number Eight Leading Cause of Death for Americans
Ending COVID
Major Causes of Death Reported by the Medical Examiner in the United States
The statistics below is a brief accumulation of the current causes of death (death rate) for the American public. The data implies that the major causes of death in the United States is following a typical pattern from the previous decade 2000-2010. Currently at the end of this decade, 2010-2020 the factors have not changed. In addition the expectation of a large discrepancy or decline in either of the main factors has not transpired.
The primarily causes of death for the American population continue to be heart disease and cancer. Both coming in as the top two causes of death for humans in the United States.
Heart disease is the number one cause of death at 655,381. Cancer is the number two cause of death at 599,274. The area of focus currently is respiratory infections such as influenza. Deaths associated to respiratory infections related to influenza/H1N1/pneumonia are listed as the 8th leading contributor. Chronic lower respiratory disease is listed as the 4th leading cause of death at 159,486. This is clearly where the discrepancy appears.
Official statistics listed: Data for the United States
Mortality rate: 867.8 deaths per 100,000 (population percentage)
Number of deaths: 2,839,205
Life expectancy: 78.7 years
Infant Mortality rate: 5.66 deaths per 1,000 live births (1st world Index)
1. Heart disease: 655,381
2. Cancer: 599,274
3. Accidents (unintentional injuries): 167,127
4. Chronic Lower Respiratory Diseases: 159,486
5. Stroke (cerebrovascular diseases/nervous): 147,810
6. Alzheimer’s Disease (nervous condition): 122,019
7. Diabetes (condition) : 84,946
8. Influenza and Pneumonia (respiratory) : 59,120
9. Nephritis, Nephrotic syndrome, and Nephrosis: 51,386
10. Suicide: 48,344
Tuesday, November 17, 2020
The Artificial Development & Inducement of Antibody Production through the Immune System
Ending COVID
Adaptive Immunity
How the Body Creates Antibodies (Artificial Inducement)
Note: This is a briefing on how antibodies are formed, however it is important to remember that most people do not currently need the COVID Vaccine at this point, in order to resume living, as most have already been exposed to the virus, and have created antibodies via a natural process through their immune system.
Starting with a return to discussing what antibodies (or immunoglobulins (Ig)) are and how they form in the human body. Antibodies are important because the immune system needs them to fight of foreign invaders into the body, such as a virus like COVID.
The antibody is a small protein molecule that is designed to identify and bind to a specific part of the virus as soon as it enters the body. The surface where the antibody binds to is called an antigen, the location on the surface is referred to as an antigenic site or epitope. There are a variety of different types of antibodies, IgG, IgA, IgM, IgD, and Ig E. Usually the amount of antibodies found in the human body is quite low, however when a virus (antigen/pathogen) enters the body the immune system responds, by increasing the amount produced.
The first time the human immune system sees a new antigen (a foreign unrecognizable pathogen) it needs to prepare to destroy it. Once an antigen/pathogen (such as a virus) enters the body, it can multiply and cause symptoms leading to illness. However, if the immune system creates antibodies targeted towards the identified antigen, then when the same antigen is seen again, the immune system is poised to confine and destroy the antigen/pathogen. This is the process known as adaptive immunity in the immune system.
Creating adaptive immunity towards viruses found in the environment, is important to maintaining good health in the human body. The primary way that the immune system creates antibodies is through the natural process known as adaptive immunity, however there are ways to induce this process artificially, one such way is by using a vaccine.
In this case, when the live pathogen (virus such as COVID) infects the body, the response is rapid and the pathogen is prevented from causing the targeted illness. In order to trigger this adaptive immunity process and immune memory a vaccine will expose the body to the targeted antigen/pathogen (such as the COVID virus), without causing the disease. And reducing the presence of symptoms in an ideal situation, preventing further damage to the human body. This is the case for those who have not already been exposed to the virus.
Although vaccines are crucial when a person is young, to help the immune system, those past that stage are usually capable of fighting of invading viruses, using their own immune system to some extent (however highly advisable to get one if not previously exposed, especially if traveling). After natural exposure to a viral strain, the body has already developed antibodies to fight of the incoming virus. Once a vaccine is widely available, those who are immuno-compromised (weak immune system), or the elderly are the ones who are going to need it most.
The rest of the population can choose whether to get vaccinated or not, depending on the strain present, and prior exposure. Similar to the yearly flu shot (influenza/H1N1, etc.), vaccines can change annually, in order to be relevant to the virus targeted. At this time it is not of extreme concern, to seize normal living in a population which has already been heavily exposed to a virus.
The Importance of Opening All Schools
Ending COVID
Why Schools Across the Country should be Opened
If you have ever broken a body part such as an arm or a leg, you will be familiar with the concept of wearing a cast. Restricting movement of a broken bone, which requires a splint, sling, brace or cast, is critical to healing, to prevent any further injury from occurring. However when you remove the cast, the first thing you will notice is how different your body part has become. Healed and placed back in the correct position it may be, but how does it actually feel. Most likely it will be very weak, flaccid, and awkward for you to move around and utilize.
This is what happens when we freeze our body parts in time, by no longer using them. It only takes 2 weeks of non-usage of our body parts for bone atrophy to start. A similar situation can also occur to our mind. The concept of "use it or lose it," is never more apparent than in the case of our nervous system. The more you learn (how to do something) the easier it becomes to do everything, usually.
This is particularly the case during the developmental stages of most humans. Starting from the age of 2 our mind works in overdrive to process the environmental information surrounding us and try to make sense of it. The more time spent in understanding our environment (from the ages of 2-18), the better we become at forming neural networks. After this stage the nervous system continues to develop throughout a lifetime, and we can continue to create new patterns as we age. However taking out the time to read and learn, along with socialize with individuals in our own peer group is crucial to our development as a species.
Educational systems allow individuals to spend an allocated time everyday enriching ourselves in learning activities which develop the nervous system. Doing so results in a lifetime of healthy functioning and enforcing societal values which are learning based. Our society is based on healthy positive social interactions with other individuals, and this is first enforced during our early educational days.
The immune systems of children are in different developmental stages than of adults. Having already been exposed to a wide variety of colds and fighting them of, they are highly unlikely to be impacted by novel viruses such as COVID. In addition, since they are at the first stage of living, and they have recently been vaccinated, they have healthy immune systems (in most cases).
While it is true that children of all ages can become infected with COVID, most who are infected, will not become as sick as an adult. In addition the vast majority will be asymptomatic. There are quite a few schools that have been open in the United States for sometime now, and they have not had any adverse effects regarding COVID openings.
Children with preexisting health conditions such as asthma, diabetes, congenital heart disease, nervous system conditions, obesity, respiratory conditions, etc. might be at a higher risk of contracting respiratory infections such as COVID. However while most children of all ages can get infected with COVID (and other viruses), most do not become as ill as adults, and are usually mild or asymptomatic.
Therefore while it is possible for children to contract COVID, it is unlikely that it will result in a life threatening circumstance, as most have mild symptoms or none at all. Hence it does not appear to be feasible to take the chance of closing the educational system preventing access to education.
Monday, November 16, 2020
The Natural Development of Antibodies as a Defense Strategy Utilized by the Human Immune System Against Viral Infections
Beyond COVID
The Natural Development of Antibodies by the Human Immune System
Presence of COVID Antibodies
How exposure to a virus results in the development of antibodies as a defense response mechanism by the human immune system.
Antibodies develop naturally in the human body through exposure of foreign entities such as viruses (SARS-COV2). The presence of antibodies help protect the human body from fighting of viral infections (such as COVID) by identifying them when they first enter the body, and block them from attaching to healthy cells.
An antibody is a protective entity that is created by the human immune system due to the presence of a foreign substance referred to as an antigen. The antibody recognizes and attaches itself to the antigen and then proceeds to attempt to remove it from the body.
When a foreign substance is able to enter the body, the first thing that occurs is that the immune system recognizes it as a foreign entity. The surface layer of antigens have molecules that are different from those found in the body, which allow the immune system to verify its uniqueness.
To eliminate the invader, the immune system calls on a number of mechanisms, including one of the most important—antibody production. Antibodies are produced by specialized white blood cells called B lymphocytes (or B cells). When an antigen binds to the B-cell surface, it stimulates the B cell to divide and mature into a group of identical cells called a clone. The mature B cells, called plasma cells, secrete millions of antibodies into the bloodstream and the lymphatic system.
Once the immune system has initiated a response to the invasion, the production of antibodies goes into overdrive producing millions at a time. The cardiovascular system circulates them via the bloodstream throughout the body. As the antibodies circulate utilizing the bloodstream, they attack and neutralize antigens that are identical to the one (alien) that triggered the immune response. The antibody first binds to the antigen in order to initiate the attack. Binding to the toxin (such as a virus (COVID)) can neutralize the poison simply by changing its chemical composition, these antibodies are called antitoxins.
Once the antibodies attach themselves to the invading virus, multiple features of the immune system can be initiated to further eliminate the virus from attacking the body. The invading microorganisms can become inactive and will no longer be able to attach and invade the human healthy cells.
At this point the initial attack of the immune system has resulted in a a series of responses primarily that regarding antibody production. The ongoing production of antibodies continues for several days until all the antigen molecules of the targeted virus (COVID) are removed. Antibodies remain in circulation for several months, providing extended immunity against that particular antigen.
Therefore, the presence of these antibodies within the human body such as those provided by the exposure of COVID, will attack the virus, and will help the body recover. In addition the ongoing presence of COVID antibodies within the body will protect the body from being infected again from the virus, similar to a vaccine.
Beyond COVID
SARS-COV2
Why we Should Move on from COVID Concerns
Saturday, November 14, 2020
Beyond COVID Previous Influenza Outbreaks throughout History
The Historical Precedence of Influenza Identification, Spread and Eventual Adaptation into the Population
What is Influenza
Influenza, also referred to as the flu, is a respiratory infectious disease that is caused by a negative-sense RNA virus (Orthomyxoviridae). The most common types of influenza viruses that impact the human population include Type A, Type B, and Type C. The virus strain spreads around the world in yearly outbreaks. An influenza pandemic occurs when a strain of the virus is transmitted to the human body (usually from another species) and spreads massively. This may also result in the identification of a new strain of the virus.
Examples of Influenza Pandemics (not comprehensive)
1918-1919
H1N1 Influenza A virus
1930's
Influenza B virus
1940's
Inactivated Flu vaccine
For inactivated Influenza A virus
1940's
Influenza B viruses discovered
Arrival of Mechanical ventilators
1942
Two dose Flu vaccine
Protection against Influenza A & Influenza B virus
1947
Flu epidemic
Changes in antigenic composition of influenza viruses
Rendered existing vaccines ineffective
Required to renew annually
Monitor international circulating viral strains
1957
Flu pandemic
H2N2 novel flu virus emerges
1960
1st Recommendation for annual Influenza vaccination
Over 65/very weak/immunocompromised
1960's
South Africa outbreak
Reservoir for influenza A virus (wild birds)
H3N2 new influenza virus emerges
pandemic
1970's
H1N1 swine flu
25% of US pop vaccinated
twice the level needed to block pandemic
1996
H5N1 virus avian influenza
Hong Kong
2003
SARS I epidemic
China
2007
H5N1
US Vaccine
2009
H1N1 pandemic
new influenza A virus
Mexico
2020
SARS-COV-2
COVID pandemic
China
There are many viral strains currently circulating worldwide and this does not interfere with daily living
Management of previous epidemics
Resulting consequences
Current management of COVID/SARS-COV-2
Beyond COVID Acquiring Test Percentages & Data Analysis
Viral infection testing and biomarker indicators are developed and utilized throughout the vast majority of the population in the case of identifying the presence of a virus during the preliminary stages of prevention. Tests are developed by utilizing viral antigens on the surface of cells infected with a specific virus. The viral antigen detection test is done with a sample of tissue that could be infected. Antibodies that are tagged (have a dye or tracer to identify as a biomarker) attach to those viral antigens when mixed with the sample to determine if a specimen is positive or not.
The most common test used for viral diagnosis are antigen detection. Methods of antigen detection include fluorescent antibody staining, immuno-peroxidase staining, etc. which are used for identifying positive and negative biomarkers to determine the appearance of a viral infection.
Once a new strain of a virus has been confirmed, it is feasible to immediately develop a complementary viral infection test to prevent the spread of the virus. After these specific tests have been developed, they can be used at the preliminary stages of identification, in order to determine the presence of a new strain of a virus within a given population, to prevent an epidemic.
Using a small subgroup of the population, the tests can be immediately used to determine the percentage infected within a population, to prevent further spread. These tests will also show the percentage of individuals who are asymptomatic, as well as have mild to moderate symptoms upon infection. While testing for virus infections is feasible during the preliminary stages to prevent an epidemic, once the percentage infected surpasses a certain point, it becomes futile. The data accumulated can be used for epidemiological studies but these can again be obtained using a much smaller sample (a hundred). It is far more feasible to test smaller subgroups of the population to obtain statistics and data rather than large ones. The critical point is to identify whether a threshold as been reached, in which the population can resume regular activities without restrictions.
Data Analysis
Additional Percentage Margins to consider regarding testing results can include: %
Percentage Infected %
Percentage Positive %
Percentage Asymptomatic %
Percentage Negative %
New Margin/Mean/Average/Median
Margin for Infected vs. Uninfected Population
Margin for Adaptability into Immune System
Margin for Antibody Presence
Percent Immunity %
Daily/Weekly/Monthly assessment
Cost Assessment Percentage (person/city/state/country)
Cost of Development
Cost of Implementation
Annual Viral Cycle
Beyond COVID - California and Texas Hit 1 Million Positive COVID Cases Milestone
The states of California and Texas have both reached over 1 million cases of positive COVID individuals. This means that over one million people have already been tested for COVID and tested positive. Asymptomatic or not, the positive results imply that, in a region with over 39 million individuals (California) and 29 million individuals (Texas) most people are testing positive. As a result of this, the chances that the vast majority of the population has already been exposed to the virus is very likely.
These testing results can be utilized as a measure of how many people have already been infected in the case of a small group of individuals, when trying to prevent a spread from occurring. However, once a certain margin has passed, it becomes futile to prevent the spread, as it has already transpired throughout the population, especially in densely populated areas such as California and Texas.
As the vast majority of the population becomes exposed in the United States, the chances of the human body developing immunity and being able to fight of the virus without the presence of a vaccine, or recovery treatment, increases. At this point it appears that the vast majority of the population has developed that capability to fight of the viral infection on its own, without a significant cost to the immune system for this viral cycle.
Beyond COVID Media Reporting that US is Easing Restrictions
News outlets arereporting that there are plans to reduce American government mandates, which is good. All states should re-open at full capacity including businesses, schools, organizations and limit restrictions. This should proceed as quickly as possible. Especially before the cold weather sits in, so people do not get further confused with symptoms from the cold, flu, bronchitis, etc. The situation has gone to far at this point for any health measures to be even remotely feasible, other than to accumulate data for epidemiological study purposes (testing results).
Almost everyone has already been exposed and for the few that might have actual ramifications, there is an approved treatment and vaccine on the market. Which would be utilized only in the worst case scenario. Deaths attributed could be from a wide combination of factors that contribute to cause of death, including previous cardiac failures, cancers, organ dysfunction, other ailments, and general aging which lead to mortality from a virus (not correctly classified). Highly advisable to resume normal life at full scale from this point except for the immune compromised, which would have been the case regardless.